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KMID : 1009020170150030243
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Clinical Psychopharmacology and Neuroscience
2017 Volume.15 No. 3 p.243 ~ p.247
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Improvement of Visuo-spatial Function Assessed by Raven’s Colored Progressive Matrices in Dementia with Lewy Bodies by Donepezil Treatment
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Yoshino Yuta
Mori Takaaki
Yoshida Taku
Toyota Yasutaka
Shimizu Hideaki
Iga Junichi
Nishitani Shusaku
Ueno Shuichi
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Abstract
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Objective: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used to assess both visual perception and reasoning ability in DLB subjects treated with donepezil.
Methods: Twenty-one DLB patients (mean age, 78.7±4.5 years) were enrolled. RCPM assessment was performed at the time of starting donepezil and within one year after starting donepezil.
Results: There were significant improvements of RCPM in the total scores between one year donepezil treatment (p=0.013), in both Set A score (p=0.002) and Set AB score (p=0.015), but trend in the Set B score (p=0.083).
Conclusion: Donepezil is useful for improving visuo-spatial impairment in DLB, but not for problem-solving impairment.
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KEYWORD
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Lewy body dementia, Cholinesterase inhibitors, Raven’s Colored Progressive Matrices, Visual spatial processing
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